Marsupilami and his family become best friends with a human family, the Du Jardin, that comes to live near them. Amanda is a Marsupilami researcher, while her husband Jean-Pierre is a computer technician that works from home and they have two children, Teo and Zoe. Teo and Marsupilami become best friends and they have lots of adventures, with both new friends and old enemies, like Backalive.